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Original Research Article | OPEN ACCESS

Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages

Hai Wang1 , Zhi-Ran Cao2

1Medical Department, The Second Central Hospital of Baoding City, Hebei 072750; 2Department of Immunology, School of Basic Medicine, Hebei University Health Science Center, Hebei 071000, China.

For correspondence:-  Hai Wang   Email: wanghai201311@163.com   Tel:+863123966325

Received: 29 April 2014        Accepted: 15 August 2014        Published: 24 September 2014

Citation: Wang H, Cao Z. Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages. Trop J Pharm Res 2014; 13(9):1415-1419 doi: 10.4314/tjpr.v13i9.6

© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the protective effects of (-)-epicatechin on lipopolysaccharide (LPS)-induced inflammation in Raw 264.7 murine macrophages and the possible underlying mechanisms.
Methods: The effects of epicatechin on LPS-stimulated production of inflammatory mediators in Raw 264.7 cells were evaluated by enzyme-linked immunosorbent assay.
Results: Epicatechin in doses of 5, 25 and 50 μM remarkably (p < 0.05) inhibited the production of pro-inflammatory mediators including nitric oxide (NO) and prostaglandin E2 (PGE2), as well as the production of pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in LPS-induced Raw 264.7 macrophages.
Conclusion: The results suggest that epicatechin can inhibit inflammatory response and may be a potential therapeutic candidate for the treatment of chronic inflammatory diseases.

Keywords: Inflammation, Epicatechin, Cytokines, Nitric oxide, Prostaglandin E2, Macrophages

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Thompson Reuters (ISI): 0.523 (2021)
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